A new path to depression relief beyond medication
Why Proliv™Rx?
Nearly 1 in 3 adults with major depressive disorder don’t find sufficient relief through antidepressants.
If this sounds familiar, there’s nothing wrong with you. Depression affects the brain in complex ways, and medication is not always enough.
Proliv™Rx was developed specifically for people living with depression when treatment has reached a standstill.
By combining breakthrough neuromodulation therapy with at-home use, Proliv™Rx offers a new path forward.
How it works
Your brain is a network of more than 80 billion neurons that communicate using tiny electrical signals. These signals share information across different regions of the brain.
In depression, communication between regions becomes disrupted, affecting mood and emotional well-being.
Proliv™Rx is designed to improve communication and connectivity across the brain. Using advanced neuromodulation, it harnesses the brain’s natural capacity to change, helping build healthier neural connections.
With its wearable headset called the NeuroRouter, Proliv™Rx delivers gentle electrical signals through electrodes placed on the forehead and the back of the head.
Much like how a router directs signals in a network, the NeuroRouter helps guide these signals precisely and non-invasively along natural nerve pathways to key regions involved in depression.
With consistent use, Proliv™Rx may helps restore balance in your brain, so you can feel better again.
What it feels like?
Proliv™Rx therapy is designed to be comfortable and pain-free.
Most people describe the sensation as a mild tingling on the scalp.
You’re comfortable and fully aware during sessions and can resume your daily activities immediately afterward.
Proliv™Rx is portable, travel-friendly, and designed to fit easily into everyday life.
What to know before starting
Proliv™Rx is:
- Prescription-based therapy
- Non‑invasive and designed for comfort
- Administered at home as part of a physician‑prescribed treatment
- Used alongside your regularly prescribed antidepressant medication
- Fits easily into daily routines
- Private
Structured home-based
therapy program
Based on your progress, your physician may recommend an additional Proliv™Rx therapy sessions to further optimize your treatment outcome.
Does it work?
In the Proliv™Rx clinical study, 87% of patients with prior inadequate response to antidepressant medications improved by one or more depression severity levels; 56% reached mild or no depression, and 31.7% achieved full remission.
Is it safe?
Yes. Proliv™Rx is FDA-approved and met the highest FDA requirements for safety.
Throughout the therapy, you can share data-driven reports with your physician, helping them stay connected to your progress and make any adjustments to your treatment plan as needed.
As a non-invasive therapy, Proliv™Rx has generally mild to moderate side effects.
What leading psychiatrists are saying
Director, Center for Advanced Imaging Research & Brain Stimulation Laboratory, MUSC
Dual board-certified psychiatrist and leading researcher in neuromodulation for treatment-resistant mood disorders.
Frequently asked questions
Who is Proliv™Rx for
Adults whose depression hasn’t improved enough with at least one antidepressant medication, and are not contraindicated for the therapy, as determined by a physician.
Proliv™Rx may still be an option for you. It’s designed specifically for treatment-resistant depression. Consult with your physician to determine if it’s appropriate for your situation.
Proliv™Rx therapy
8 weeks, with two daily sessions (about 40 minutes each). our physician may extend it for another 8 weeks to maximise your clinical outcome.
Many patients report improvements within the first few weeks of treatment, though individual responses may vary. Your physician will monitor your progress throughout the program.
You should continue taking your prescribed medications unless your physician advises otherwise. Proliv™Rx is designed to work alongside your current treatment plan.
Most patients describe a gentle tapping or pulsing sensation. The treatment is non-invasive and generally well-tolerated. Your care team will ensure you’re comfortable throughout each session.
Proliv™Rx has been clinically tested and is FDA-cleared for the treatment of depression. As with any medical treatment, your physician will assess whether it’s appropriate for you based on your medical history.
Treatment sessions are conducted under medical supervision. Your physician will provide specific guidance about your treatment setting based on your individual needs.
Yes, your physician will monitor your progress throughout the treatment program and adjust your care plan as needed to optimize outcomes.
While both are non-invasive brain stimulation therapies, Proliv™Rx uses a different approach and technology. Your physician can explain the specific differences and which option is best for you.
If you need to miss a session, contact your care team as soon as possible. They will work with you to reschedule and ensure you receive the full benefit of the treatment program.
Most patients can resume normal activities immediately after treatment. However, your physician will provide personalized guidance based on how you respond to the therapy.
Insurance coverage
Coverage varies. Your doctor or care team can help you understand your options.